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Schuller Lab - CryoEM of molecular machines


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Human-induced climate change is one of the greatest challenges of the still young century. We are a team of scientists who agree that we should dedicate our basic research to combat it. Therefore, the Schuller Lab focuses its research on these questions: How can microorganisms fix the greenhouse gas CO2? How do they respond to changing environmental inputs?

Our laboratory specializes in single-particle CryoEM . This method enables us not only to determine high-resolution structures of both soluble and membrane-bound multiprotein complexes, but also to uncover their molecular dynamics. We believe that determining the structure of a bioenergetic machine is the key to understanding its function and creating a roadmap for its manipulation. 

Bacterial biochemical pathways hold a wealth of opportunities for synthetic biology approaches that could be used to create improved microbes for the production of chemical compounds, to generate solar fuels and to sequester CO2 to combat global warming. 

We are located on the Lahnberge in the historic city of Marburg. We are part of the SYNMIKRO research centre, a cooperation between Philipps University and the nearby Max Planck Institute for Terrestrial Microbiology. 

ERC-Starting Grant 

22.November 2022

Jan has been awarded with an ERC-StG for the project TWOCO2ONE. We aim to discover the mechanistic basis of CO2 fixation in the ancient Wood-Ljungdahl pathway and inspire novel solutions for biotechnology and synbio. 

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