Human-induced climate change is one of the greatest challenges of the still young century. We are a team of scientists who agree that we should dedicate our basic research to combat it. Therefore, the Schuller Lab focuses its research on two main questions: How can bacteria fix the greenhouse gas CO2 and how do they respond to changing environmental inputs.
Our laboratory specializes in cryoEM single particle analysis. This method enables us not only to determine high-resolution structures of membrane-bound multiprotein complexes, but also to uncover their molecular dynamics. We believe that determining the structure of a bioenergetic machine is the key to understanding its function and creating a roadmap for its manipulation.
Bacterial biochemical pathways hold a wealth of opportunities for synthetic biology approaches that could be used to create improved microbes for the production of chemical compounds, to generate solar fuels and to sequester CO2 to combat global warming.
We are located on the Lahnberge in the historic city of Marburg. We are part of the SYNMIKRO research centre, a cooperation between Philipps University and the nearby Max Planck Institute for Terrestrial Microbiology.
What is new?
Cell Paper Published
08. July 2021
This very important plastid protein (VIPP1) turned out to be a great collaborative story with the Engel and Schroda labs. In this study we solved the high-resolution structure of VIPP1 by cryo-EM, revealing the mechanisms by which it oligomerizes and binds lipids. In vivo structure-directed mutagenesis further implicates VIPP1 lipid binding in the formation of thylakoid convergence zones, as well as the maintenance of thylakoid integrity under high-light stress.